Sizzla, Elephant Man, Richie Spice and Mr Vegas will perform on the event, which also celebrates the station’s 23rd anniversary.
Anthony B, I-Wayne, Bugle and Jahmiel are also on the card.
“We have had an excellent run since we first graced the airwaves in New York 23 years ago. We could not have been on air this long without the support of our many clients, our dedicated staff and, most importantly, our valued listeners,” said Irie Jam CEO Bobby Clarke.
The show marks a return to the Big Apple for Sizzla, who was unable to perform in the United States due to his visa being revoked.